It is with great pride and immense pleasure that we introduce the Creative Bioarray QualiStem® Alkaline Phosphatase Live Staining Kit which provides a fast, simple and sensitive method for AP detection without fixing the cells. The reagent is nontoxic to the cells and the fluorescent signal will be discharged from the cells by exocytosis completely within two hours after removal of the staining solution, allowing the cell to be used for follow-up studies
Details
WNK1, a WNK type protein kinase, contains a small N-terminal domain followed by a kinase domain and a long C-terminal tail. The protein is cytoplasmic and has been shown to regulate both the c-Jun N-terminal kinase pathway and the actin cytoskeleton in vitro. WNK1 has been identified as the gene mutant in pseudohypoaldosteronism type 2, also known as Gordon hyperkalemia-hypertension syndrome, which is a rare autosomal dominant form of volume-dependent, low-renin hypertension. Disease-causing mutations are large intronic deletions that increase WNK1 expression. At least two variants of WNK1 are produced by alternative splicing.
Additional Information
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