It is with great pride and immense pleasure that we introduce the Creative Bioarray QualiStem® Alkaline Phosphatase Live Staining Kit which provides a fast, simple and sensitive method for AP detection without fixing the cells. The reagent is nontoxic to the cells and the fluorescent signal will be discharged from the cells by exocytosis completely within two hours after removal of the staining solution, allowing the cell to be used for follow-up studies
Details
Ubiquitin Specific Protease 4 is a hydrolase that deubiquitinates target proteins such as the receptor ADORA2A and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. This protein plays a role in the regulation of quality control in the ER. USP4 interacts with RB1 (both dephosphorylated and hypophosphorylated forms) and with ADORA2A (via cytoplasmic C-terminus); The interaction is direct. Iit also interacts with RB1, RBL1 and RBL2. It is overexpressed in small cell tumors and adenocarcinomas of the lung compared to expression of the wild-type in the lung (at protein level). USP4 is expressed in the hippocampal neurons.
Additional Information
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