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TOR

Catalog Number: EXA-X1973P

 

Details

Mammalian target of Rapamycin (mTOR), also known as FKBP12-rapamycin-associated protein (FRAP) is a ~280 kDa serine/threonine kinase and a key modulator of cell growth and protein synthesis. mTOR is implicated in cancer and neurite plasticity, and plays a central role in mediating phosphoinositide 3-kinase (PI3 kinase) and Akt/PKB signals for cell growth, proliferation, and protein translation via ribosomal S6 kinase (S6Ks) and translation regulator eIF4E-binding protein 1. mTOR is differentially phosphorylated on threonine 2446 and serine 2448 in response to nutrient status and growth factor stimulation.

Additional Information

Suppliers Exalpha
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