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TCF-3/4

Catalog Number: EXA-X1071M

 

Details

TCF-3 and TCF-4 (T cell factor-4) are a members of the TCF/LEF (lymphoid enhancer factor) family of transcription factors. Members of this family along with ? catenin, are involved in mediating Wnt signaling by transactivating downstream genes. TCF-4 generates transcriptionally active complexes with ? catenin in colon carcinoma cells. Expression of TCF-4 is highest in the CNS and intestinal epithelium where Wnt signaling also plays an essential role in development. Aberrant TCF-4 transcription activity has been implicated in carcinogenesis of intestinal and mammary epithlia. TCF-3 appears to be expressed exclusively of TCF-4 in the hair follicles, stomach epithelium, and keratinocytes of the skin.

Additional Information

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