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STAT3

Catalog Number: EXA-X1995M

 

Details

The signal transducer and activator of transcription (STAT) family of transcription factors is composed of seven family members (STATs 1, 2, 3, 4, 5A, 5B and 6) that are involved in many cell processes (apoptosis, anti-apoptosis, cell differentiation and proliferation), depending upon the cell type. STATs are activated by ligand binding to cytokine receptors and other receptors associating with Janus kinase (JAK) family members that phosphorylate STAT proteins, causing them to assemble and translocate to the nucleus. In the nucleus, phosphorylated STAT protein complexes bind to DNA and regulate the transcription of particular genes.

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