It is with great pride and immense pleasure that we introduce the Creative Bioarray QualiStem® Alkaline Phosphatase Live Staining Kit which provides a fast, simple and sensitive method for AP detection without fixing the cells. The reagent is nontoxic to the cells and the fluorescent signal will be discharged from the cells by exocytosis completely within two hours after removal of the staining solution, allowing the cell to be used for follow-up studies
Details
Recognizes specifically a protein of ~60kDa, identified as human retinoic acid receptor ? (hRAR?). It does not react with hRAR?, hRAR? isotypes, and human retinoid X receptor (hRXR). Retinoids are metabolites of vitamin A (retinal) and are believed to represent important signaling molecules during vertebrate development and tissue differentiation. Two families of retinoid receptors have been identified. Retinoic acid receptors (RARs) include RAR?, RAR? and RAR?, each of which has a high affinity for all-trans retinoic acids and belongs to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. The ligand binding domains of the RARs are highly conserved and RAR isoforms are expressed in distinct patterns throught development and in the mature organism. Members of the retinoid X receptor (RXR) family, RXR?, RXR? and RXR?, are activated by 9-cis-retinoic acid, a stereo- and photoisomer of all-trans-RA that is expressed in vivo in both liver and kidney and may represent a widely used hormone.
Additional Information
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