It is with great pride and immense pleasure that we introduce the Creative Bioarray QualiStem® Alkaline Phosphatase Live Staining Kit which provides a fast, simple and sensitive method for AP detection without fixing the cells. The reagent is nontoxic to the cells and the fluorescent signal will be discharged from the cells by exocytosis completely within two hours after removal of the staining solution, allowing the cell to be used for follow-up studies
Details
Tyrosine-protein phosphatase, non-receptor type 1 (PTP1B) also know as Protein-tyrosine phosphatase 1B, PTPN1 is a PTP (protein tyrosine phosphatase) first isolated from human placenta. The protein is unrelated to other known phosphatases but is similar to common leukocyte antigen (CD45) and to LAR a homolog of the neural adhesion molecule NCAM. PTP1B negatively regulates insulin sensitivity by dephosphorylating the insulin receptor. Akt is a ser/thr kinase effector of insulin signaling that phosphorylates substrates at the consensus motif RXRXXS/T. PTP1B contains the Akt phosphorylation motif (RYRDVS50), and PTP1B (but not mutants with substitutions for Ser50) are phosphorylated by Akt. Insulin stimulation also causes a significant increase in phosphorylation of PTP1B.
Additional Information
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| Presentation | N/A |