Protein Tyrosine Kinase

The importance of protein tyrosine phosphorylation in such diverse cellular processes as proliferation, differentiation and gap-juunction communication is reflected in the enormous number of protein tyrosine kinases that have been identified and described in the last thirty years. The roles played by anomalies in expression of these enzymes in cancer and other disease states has made them targets of intense research interest as part of the ongoing search for new therapies. Tyrosine kinases purified from mammalian tissue sources may be valuable to the study of generalized tyrosine phosphorylation or for the generation of specific phosphorylated peptides.Our PTK enzyme has been purified from porcine kidney utilizing both classical chromatographic procedures as well as affinity chromatography on immobilized substrate of random amino acid copolymers containing tyrosine, but not serine or threonine.