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Paired Basic Amino Acid Cleaving System 4 (PACE4) (PCSK6)

Catalog Number: EXA-X2227P

 

Details

PACE4 is a Serine S8 type protease that cleaves precursor proteins at paired basic amino acid processing sites. Several PACE4 substrates have been identified, including transforming growth factor beta-related proteins, proalbumin and von Willebrand factor. At least eight alternatively spliced transcript variants encoding different isoforms have been reported. In mouse, PACE4 has been shown to increase tumor cell invasiveness, and thus enhance tumor progression.

Additional Information

Suppliers Exalpha
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