It is with great pride and immense pleasure that we introduce the Creative Bioarray QualiStem® Alkaline Phosphatase Live Staining Kit which provides a fast, simple and sensitive method for AP detection without fixing the cells. The reagent is nontoxic to the cells and the fluorescent signal will be discharged from the cells by exocytosis completely within two hours after removal of the staining solution, allowing the cell to be used for follow-up studies
Details
A receptor for the C-X-C chemokine CXCL12/SDF-1, CXCR4 transduces a signal by increasing the intracellular calcium ions level. It is involved in haematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodelling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Clone 12G5 has been shown to block infection by certain isolates of HIV-1 and HIV-2 and is specific for CXCR4 and does not react with IL8R-A, CCR1, CCR2b, CCR3, CCR4, and CCR5. CXCR4 is upregulated in response to activation of PBMCs for 3-5 days with PHA.
Additional Information
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