CD7 FITC - CD13&33 PE

Identification of human T lymphocytes in multiple stages of T cell development, including a major subset of mature peripheral T cells. CD7 antigen is often increased on T leukemic cells. The CD7 molecule is a 40,000 M.W. surface antigen that is expressed on T-Lymphoid and myeloid precursors in fetal liver and bone marrow. CD13 is a membrane enzyme Aminopeptidase N. Identification of human monocytes and granulocytes expressing the 150 kD M.W. surface antigen. Myeoid cells in regenerating bone marrow will have an increased expression of CD13 in comparison with normal bone marrow myeloid cells. Identification of human Monocytes(bright) and Granulocytes (dim) expressing the 67K M.W. surface antigen. CD33 is also found on CFU-mix, CFU-GM, CFU-Meg, a portion of BFU-E, myeloblasts, promyelocytes, myelocytes, metamyelocytes but not early precursors.