ATP-Binding Cassette, Sub-Family B (Mdr/Tap), Member 1 (Abcb1)

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13). Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases.