We are pleased to announce that we've added three new P450 catalytic systems to our CypExpress™ line. CypExpress™ 1A1, CypExpress™ 2B6, and CypExpress™ 2E1 are now available.
CypExpress™ is a stable dry biocatalytic system containing both an individual recombinant human P450 and recombinant oxidoreductase along with cofactors and antioxidant systems produced in a eukaryotic expression system.
The identification and charachterization of metabolites is a critical step in the process of bringing any new chemical entity to market. Until now, the synthesis and purification of several milligrams of a given P450 metabolite required expensive E. coli recombinant enzymes or liver microsomes which can yield complex product mixtures and involve difficult isolation procedures.
CypExpress™ provides for robust metabolite identification and scale-up production while reducing the time and expense involved.
Advantages
- Coexpressed unmodified full-length human recombinant CYP and oxidoreductase
- Provided as a dry powder that is stable at room temperature or frozen
- Reactions can be performed in Tris or Phosphate buffers
- Can be pelleted and used for multiple reaction cycles
- Provides clean HPLC profiles for easy metabolite ID and purification
- Produces much more metabolite faster and at a lower cost
Products
CypExpress™ 1A1 NEW!
CypExpress™ 1A2
CypExpress™ 3A4
CypExpress™ 2B6 NEW!
CypExpress™ 2C9
CypExpress™ 2C19
CypExpress™ 2D6
CypExpress™ 2E1 NEW!
for a full quote - please e-mail us at info@huntingtree.co.nz