CypExpress™ is a stable dry biocatalytic system containing both an individual recombinant human P450 and recombinant oxidoreductase along with cofactors and antioxidant systems produced in a eukaryotic expression system.
The identification and charachterization of metabolites is a critical step in the process of bringing any new chemical entity to market. Until now, the synthesis and purification of several milligrams of a given P450 metabolite required expensive E. coli recombinant enzymes or liver microsomes which can yield complex product mixtures and involve difficult isolation procedures.
CypExpress™ provides for robust metabolite identification and scale-up production while reducing the time and expense involved.
Advantages
- Coexpressed unmodified full-length human recombinant CYP and oxidoreductase
- Provided as a dry powder that is stable at room temperature or frozen
- Reactions can be performed in Tris or Phosphate buffers
- Can be pelleted and used for multiple reaction cycles
- Provides clean HPLC profiles for easy metabolite ID and purification
- Produces much more metabolite faster and at a lower cost
More Information
To discuss your specific needs, please contact an OBR technical representative at info@oxfordbiomed.com or 800-692-4633 ext. 12. For a complete list of products, please visit OBR's Website.
Alternatively, get in contact with us locally at info@huntingtree.co.nz