DNA damage can take many forms including oxidative damage, hydrolytic damage (loss of bases) and strand breaks. Continuous DNA damage has been implicated in age-related development of a variety of cancers including colon, breast and prostate.
In this article we discuss various assay kits to help measure DNA damage in a quick and reliable way. Read on for further details.
8-OHdG DNA Damage ELISA
8-hydroxydeoxyguanosine (8-OHdG) is a popular and ubiquitous marker of oxidative stress.
Our OxiSelect™ Oxidative DNA Damage ELISA Kit provides a powerful, well-published method for rapid, sensitive quantitation of 8-OHdG in DNA samples.
TECH CORNER: Stability of the 8-OHdG DNA Damage Marker
Q: We are using your OxiSelect™ 8-OHdG DNA Damage ELISA. Once the DNA of our sample has been extracted, does it need to be immediately used in the assay, or can it be frozen for later testing?
For more Frequently Asked Questions on Oxidative Stress click here.
Don't see your question answered on our FAQ page? Contact our scientists here.
UV Induced DNA Damage Assays
Absorption of ultraviolet (UV) light produces two predominant types of DNA damage: cyclobutatne pyrimidine dimers (CPD) and pyrimidine (6-4) pyrimidone photoproducts (6-4PP).
Our OxiSelect™ Oxidative UV-Induced DNA Damage Assay Kits provide rapid detection and quantitaiton of CPD or 6-4PP. Kits are available in ELISA format for isolated DNA or intact cells, and also in a cellular staining format.
It is with great pride and immense pleasure that we introduce the Creative Bioarray QualiStem® Alkaline Phosphatase Live Staining Kit which provides a fast, simple and sensitive method for AP detection without fixing the cells. The reagent is nontoxic to the cells and the fluorescent signal will be discharged from the cells by exocytosis completely within two hours after removal of the staining solution, allowing the cell to be used for follow-up studies
Since the Monkeypox was first detected on 7 May 2022 in the United Kingdom, more and more cases have been confirmed in non-endemic countries, Creative Biogene decided to do our share for supporting the scientific community against this disease and would like to introduce our Monkeypox Virus Real Time PCR Kit.