DNA damage can take many forms including oxidative damage, hydrolytic damage (loss of bases) and strand breaks. Continuous DNA damage has been implicated in age-related development of a variety of cancers including colon, breast and prostate.

In this article we discuss various assay kits to help measure DNA damage in a quick and reliable way. Read on for further details.

8-OHdG DNA Damage ELISA

8-hydroxydeoxyguanosine (8-OHdG) is a popular and ubiquitous marker of oxidative stress.

Our OxiSelect™ Oxidative DNA Damage ELISA Kit provides a powerful, well-published method for rapid, sensitive quantitation of 8-OHdG in DNA samples.

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TECH CORNER: Stability of the 8-OHdG DNA Damage Marker

Q: We are using your OxiSelect™ 8-OHdG DNA Damage ELISA. Once the DNA of our sample has been extracted, does it need to be immediately used in the assay, or can it be frozen for later testing?

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For more Frequently Asked Questions on Oxidative Stress click here.

Don't see your question answered on our FAQ page? Contact our scientists here.

UV Induced DNA Damage Assays

Absorption of ultraviolet (UV) light produces two predominant types of DNA damage: cyclobutatne pyrimidine dimers (CPD) and pyrimidine (6-4) pyrimidone photoproducts (6-4PP).

Our OxiSelect™ Oxidative UV-Induced DNA Damage Assay Kits provide rapid detection and quantitaiton of CPD or 6-4PP. Kits are available in ELISA format for isolated DNA or intact cells, and also in a cellular staining format.

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OxiSelect™ Comet Assays

The comet assay is a well-published method for measuring cellular DNA damage.

Our OxiSelect™ Comet Assays provide a fast, convenient way to measure DNA damage on a macro level, regardless of the source or nature of the damage.

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Our experienced scientists can help guide you; please contact them with any questions at tech@cellbiolabs.com.

For more information visit www.cellbiolabs.com.