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![]() Product News -Heat Shock 40kD Protein 4 ELISA and antibody
DNAJA1 is most identical to YDJ1, which may be involved
in the transport of certain proteins into the mitochondria
and endoplasmic reticulum.Transplantation experiments with
fluorescence-tagged spermatogonia into Dja1 - mice revealed
a primary defect of Sertoli cells in maintaining
spermiogenesis at steps 8 and 9.
In Sertoli cells of Dja1 - mice,
the androgen receptor markedly accumulated with enhanced
transcription of several androgen-responsive genes,
including Pem (MUC1) and testis-derived transcript (TES).
Disruption of Sertoli-germ cell adherens junctions was also
evident in Dja1 - mice. Experiments with Dja1 - fibroblasts
and primary Sertoli cells indicated aberrant androgen
receptor signaling.
For more information on this or any other USCN product, please contact us by phone on (09) 4792067 or by e-mail.
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